The Miracle of TUDCA

I am so very excited about the potential that this simple supplement holds in contributing to my personal healing, physical fitness and for the potential healing of friends and family. I will be sharing here my own personal experiences with this amazing supplement and some hopes of healing that I hold with its use for myself and others based on studies that have been released on TUDCA (Tauroursodeoxycholic acid )( 1 ).

Through the better part of my life, my digestive system had challenges. The challenges did not affect my ability to function and were never picked up or addressed by the medical physicians that followed me over the years. In late 1998, early 1999, this – what seemed to be a minor health challenge, finally became a major one when I could no longer eat. The mouth stopped salivating, even the eyes had almost no ability to tear. The nails and hair stopped growing and the nails were developing yellow and orange coloration, even in the whites of the eyes. The upper right side of the abdomen was a little distended.

What I learned from this experience was that it is normal to have regular bowel eliminations daily. That they need to be at least 12 to 18 inches long when eating full healthy meals. That healthy eliminations should release what was eaten within 18 to 24 hours maximum. The health of the digestive organs including the intestines and especially the liver are necessary in order to live a healthy life. When the intestines and liver do not work optimally, this could affect the lymphatic system. If the lymphatic system is compromised, the detoxification and immune mechanisms could be affected. These organ systems are to eliminate toxins from the from the body and handle environmental exposures. And if any of these organs fail to function optimally, the body is susceptible to developing disease.

I learned that environmental toxins which include metals and heavy metals, radioactive particles, chemicals, electromagnetic radiation, radiation and wifi can disrupt and/or degrade the normal function of the body. And if not addressed, over time could promote a weakening of the body’s natural defenses which would render the body susceptible to a variety of pathogens all of which contribute to burdens on the body’s ability to perform its intended function and prevent disease in the body.

I learned that not all bodies are equal in their ability to handle environments. The factors involve the health they entered this world with along with the environment they have been exposed to, their genetic predispositions as well as their mental emotion and spiritual states or tendencies. All of these are determining factors on how different people will thrive in the same environment.

In June 2008, while I was enjoying one of the peak health experiences in this entire life, something went terribly wrong. In the office at the workplace that I had been working, I developed a runny nose – something I never experienced unless I had a cold which this was not , a headache , brain fog, difficulty to breathe, heart palpitations and an elevated heart rate, among other symptoms. Others in the office also felt unwell. But I was the only one who developed increasing and eventually severe reactions that progressed over the days that followed. These symptoms coincided with the air conditioning system that had been turned on for the first time in the season.

In the days that followed, the initial symptoms persisted and I became intolerant to the air in the office to the degree that I eventually could not return . With every exposure, I became more unwell and new symptoms would develop. I eventually became intolerant to thing s in my home that I use to be able to tolerate. My heart rate elevated to 100 beats per minute and did not drop until almost 3 months later, after applying a strict naturopathic healing protocol and long, deep meditations.

In the weeks that followed the initial reaction, I developed a sense of a blockage in the upper right abdominal area that years later also developed pain in the area. The naturopathic protocols that worked for me until that time eventually stopped working and my ability to digest foods, absorb and retain nutrients, eliminations among other functions in the body deteriorated and diminished in function. For years I would share this with medical and naturopathic physicians with no solution in sight.

Hearing a few times on some social media groups this year, about TUDCA and how it helped their digestion improve, eventually caught my attention enough to research a little about it. I was encouraged to hear that TUDCA was naturally produced in the body and that natural products might be available on the market. I was still hesitant to try something like this without understanding more about its effects, side effects and checking with my physician(s) first.

I started to search online for evidence of TUDCA’s efficacy regarding digestive health. Some of the first links that I found were sites promoting TUDCA for sale to athletes for muscle recovery, muscle building and stamina support. Muscle health could be related to liver health so I directed my search toward TUDCA support of the liver. (2 ) This report increased my interest in TUDCA. It discussed the successes encountered using TUDCA for neurodegenerative diseases like Alzheimers ( 2 ,3), Parkinsons ( 2) and Huntington’s ( 2 ) diseases. It discussed successes in the treatment of diseases of the eyes ( 2 ,4, 5, 6), kidneys ( 2 ) , cardiovascular system ( 2, 7, 8 ), It also discussed success treating obesity ( 2 ), diabetes ( 2 , 9, 10) and gastrointestinal disorders ( 2 , 11) . Since using TUDCA, as I experienced some improvements and reversals in some of the conditions that developed through the years, I searched for information relating TUDCA to these conditions and stumbled across reports discussing successes in treating some of the conditions I was experiencing levels of healing in, as well as other conditions that friends and family have: ALS, (12), stroke ( 13 ), blood clot disorders (13), liver diseases ( 1 , 2 , 14, 15, 16), pulmonary fibrosis (17), arthritis (18), thyroid disorders ( 1 ) sleep disorders ( 19). support of the digestive system and prevention of diseases developed following the removal of the gallbladder (20), Neuron repair and regeneration and neuroninflammation reduction or protection ( 21, 22, 23, 24, 25, 26), Asthma ( 27 ). I continue to find more and more studies citing successful results when treatments are used in conjunction with TUDCA.

The more I read about this supplement the more I felt that this is something that I probably need for my body. At the time I decided to go ahead with using this supplement, I was experiencing increasing concerning health issues, following prescribed protocols while under the care of a functional medicine clinic – but decided not to wait for their input. When I shared my decision to use this supplement, the clinic agreed with my decision to take this supplement.

Almost 2 months ago, I started taking bovine based TUDCA ( 28 ). At the time, I was experiencing some very strong symptoms of elimination blockages in the body that were very concerning. In the weeks following a strong allergic reaction due to histamine overload in the body, the concerning symptoms developed increasingly. I will discuss some insights I gained from the allergic reaction that I experienced in a future blog entry, After eating or drinking anything other than water, I would experience intense nausea that lasted the entire day. If I would drink water any time in the day after eating or drinking something, the nausea would intensify. The exhaustion was devastating and lost my physical strength. I could barely carry an empty bag. Medical tests revealed nothing so I turned toward naturopathy for answers. How I finally restored my health from this condition, i will leave for another time.

About 2 weeks following the allergic reaction, I began to experience an increased anxiety in the body that did not seem to be associated with anything mental or emotional. Recognizing this to be a body initiated experience, I remained mindful not to be triggered, to associate it with any mental or emotional state or experience from the past or present. In a future blog, I will elaborate on my perspective about how I believe that not all mental emotional triggers are initiated from life interactions in the outside world. But rather, some could be a result of environmental and/or physical conditions and/or spiritual ones. I already touched lightly on this subject in an earlier blog entry. I intend to elaborate on this in the future.

Before the allergic reaction my normal blood pressure and heart rate measured consistently on the low side around 110/60 (normal BP is 120/80) – my BP tends to be on the low side of normal) with a heart rate range from 50 to 60 (a possible indication of adrenal fatigue). I had started to measure my blood pressure at home following a reaction I experienced in 2011 that left me feeling unwell – with fluctuating symptoms of dizziness, heart palpitations, body anxiety and general strange sense of being unwell along with a variety of other symptoms. These symptoms included yoyoing of blood pressure and heart rate, from very high to very low It was then that I began to document the fluctuations and recognized certain symptoms to be aligned with specific levels measured in the BP and heart rate. This association helped me navigate through this challenging period. It took over 6 years before the blood pressure regulated and I did not experience these symptoms again until 16 days after the allergy reaction I experienced in May this year., I decided to pull out the BP measuring device and it tended to measure on the higher side of my normal blood pressure, closer to the accepted normal.. Two days later (eighteen days after the allergic reaction), following a new reaction with symptoms worsening the BP measured higher than my normal tending toward the high side 131/70 58 and the following day (19 days after the allergic reaction) measured as high as 171/86 69 when the symptoms presented. Fortunately the measurements did not reach the highs and super lows of previous years. But these fluctuations affected my ability to function and I felt pretty unwell.

Nineteen days after the allergic reaction, while lying down at night, I experienced a sensation in the right leg as though something had dislodged from there and instants later I experienced a sensation in the right side of the heart area as though a ribbon had entered the lower chamber and fluttered until it passed through the entry point only to experience similar a little higher up and over to the left. This sensation was experienced again every second or minutes or so for the next month.
The following days after the sensation experience of object(s) releasing, I began to experience increasing chest pains or tensions as well as discomforts in the head and upper abdominal area. I was very tired and a little out of breath when I attempted light activities. These symptoms persisted for the next month. At times the symptoms became so intense it seemed as though these areas in the body were almost completely blocked.

Twelve days after the experience of the moving object(s) in the heart area and about one month after the strong allergic reaction I began taking a bovine based TUDCA. Within a minute or two after taking the first dose, I experienced at a spot in the liver area (like a blocked feeling) that had been there for over 10 years fan upward and move 1 to 2 inches. Within the minutes and hours that followed, I began to experience continued incremental relief in all the symptoms that I had shared above and more that I did not share here. By the next day the symptoms had downgraded from extreme and severe and disabling suffering to discomfort and no suffering. From the moments after taking the first dose I began to experience areas in the liver and the rest of body show signs of resuming of some level of function when after many years there was diminished function to none.

Over the weeks digestion had improved. Until then I was not able to eat much without feeling ill or feeling that the food would just sit there the entire day. Salivation increased and the time the food would sit in the stomach kept reducing. After a month on the bovine based TUDCA and the supplements that were added during these weeks (Japanese Knotweed tea and Japanes Knotweed tincture and food based Nattokinase) I was becoming more and functional and mobile.

Since late January I was experiencing increasing joint tendon and ligament inflammation that at times was crippling. I had begun dosing on proteolytic enzymes (eventually to 11 pills 2x/day) which helped relieve most of the crippling effects within days. I doubled the dose after experiencing what seemed to be object(s) releasing from the leg into the heart area. I started taking proteolytic enzymes early this year because of other symptoms I was experiencing (strange bloating and gas) which suggested an enzyme depletion in the body. I decided to double the dose because proteolytic enzymes could help dissolve scar tissue, blood clots and reduce inflammation in the body. In a future entry I will speak more about proteolytic enzymes and the reasons why I elected to delay taking Nattokinase in conjunction.

It seems that the other two supplements and possibly the proteolytic enzymes helped magnify the results of the bovine based TUDCA and vice versa. With each addition I was experiencing leaps on the road to well being. Since taking all these supplements together, the redness in the joints had disappeared except on on two joints that were most deformed from osteoarthritis. The redness did however eventually reduce to a light pink. And the deformation has reduced by 80% in all the joints except for a few that reduced to at least 50% and continue to reduce every week that passes.

About two weeks ago overall pain in the body had significantly reduced. Joint flexibility has returned almost 70% and mobility has returned at least 70%. I no longer need take great care standing up from a seated position, sitting down, walking up and down stairs...
Numbness and swelling in the extremities are almost completely gone. I am able to sit upright without needing to support the back for much longer periods with the back muscles feeling strong.For the past 8 years I have been unable to sit upright for more than a minute or so without needing support and/or without feeling like there is no strength in the back muscles. I am sleeping more deeply at night. It has been about 4 years since I have been able to sleep this deeply.

Two days ago, I replaced the bovine based TUDCA with a newly released on the market, vegan TUDCA ( 29 ) that is touted to be a superior product on the market regarding purity, consistency, efficacy and potency – manufactured using cutting edge technology. The formula offers something extra that other products on the market do not offer. This formula supports all 3 detox functions of the liver whereas the other products only support 1 liver detox function. I experienced similar speed of positive symptoms with the vegan TUDCA as I did with the bovine based TUDCA – moments after taking the 1st dose, areas in the body resumed levels of functionality that had not been experienced in many years and even decades. I look forward to seeing how much more recovery will be had and accelerated with this vegan TUDCA.

References

1. TUDCA Benefits: Linked to Bile, Liver, and Gut Health
http://bit.ly/37Fks17

2. The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030606/

3. TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice.
https://www.ncbi.nlm.nih.gov/pubmed/22438081

4. Neuroprotective strategies for retinal disease
https://www.researchgate.net/publication/323361240_Neuroprotective_strategies_for_retinal_disease

5. TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation.
| Renewal and elimination of the aged photorecepto “
https://www.ncbi.nlm.nih.gov/pubmed/25804419

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6. Tauroursodeoxycholic Acid (TUDCA) Protects Photoreceptors from Cell Death after Experimental Retinal Detachment
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024245

7. Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.1901

8. Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex
https://www.sciencedirect.com/science/article/pii/S1818087617305482

9. Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791476/
Both TUDCA and PBA have been attributed to antiapoptotic, anti-inflammatory, antioxidative, and immunomodulation effects [18, 25, 27]. A few studies indicate that TUDCA and PBA enhance the adaptive capacity of ER and prevent insulin resistance [25, 26].

10. The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes
“TUDCA Improved Metabolic Flexibility in STZ Mice”
https://www.frontiersin.org/articles/10.3389/fphys.2019.00561/full

11. Functions of Melatonin from A to Zzz’s
” … Studies suggest that both melatonin and TUDCA support a healthy microbiome … “
https://microbeformulas.com/blogs/microbe-formulas/functions-of-melatonin-from-a-to-zzz-s?rfsn=2975732.8e35c4&utm_source=refersion&utm_medium=affiliate&utm_campaign=2975732.8e35c4

12. Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/25664595

13. Study Finds Bile Acid Reduces Apoptosis; Protects Against Neurological Injury After Hemorrhagic Strokes In Rats
https://www.sciencedaily.com/releases/2003/04/030422075329.htm

14. Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:
The positive effect of glutamine on intestinal mucosal integrity can be increased if it is used with TUDCA, which also has hepatoprotective and immunomodulatory features.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115941/

15. Ca²⁺-Dependent Cytoprotective Effects of Ursodeoxycholic and Tauroursodeoxycholic Acid on the Biliary Epithelium in a Rat Model of Cholestasis and Loss of Bile Ducts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606491/?tool=pmcentrez
” Chronic cholestatic liver diseases are characterized by impaired balance between proliferation and death of cholangiocytes, as well as vanishing of bile ducts and liver failure … The administration of UDCA or TUDCA prevented the induction of apoptosis and the loss of proliferative and functional responses observed in the bile duct ligation-vagotomized …”

16. Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease.
https://www.ncbi.nlm.nih.gov/pubmed/29139555

17. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176071

18. Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes.
https://www.ncbi.nlm.nih.gov/pubmed/31143889

19. Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in Male Mice
Sleep Fragmentation Attenuates Leptin Receptor Signaling in the Hypothalamus, which is Restored by TUDCA Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262953/

20. [Rationale for the use of bile salts after cholecystectomy: results of a controlled clinical study using tauroursodeoxycholic acid (TUDCA)].
https://www.ncbi.nlm.nih.gov/pubmed/8010582

21. Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation
These data suggest that TUDCA supplementation ameliorates neuroinflammation through reduced infiltration of immune cells and decreased microgliosis and astrocytosis.
https://www.biorxiv.org/content/biorxiv/early/2019/05/07/627356.full.pdf

22. Tauroursodeoxycholic acid: more than just a neuroprotective bile conjugate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319238/

23. Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro.
https://www.ncbi.nlm.nih.gov/pubmed/31377809

24. Tauroursodeoxycholic acid: more than just a neuroprotective bile conjugate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319238/

25 Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling.
https://www.ncbi.nlm.nih.gov/pubmed/25483094

26. Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats
https://www.researchgate.net/publication/317096977_Tauroursodeoxycholic_Acid_Enhances_Mitochondrial_Biogenesis_Neural_Stem_Cell_Pool_and_Early_Neurogenesis_in_Adult_Rats

27. Effect of a chemical chaperone, tauroursodeoxycholic acid, on HDM-induced allergic airway disease.
https://www.ncbi.nlm.nih.gov/pubmed/27154200

28. TUDCA Nutricost
https://nutricost.com/collections/sports-nutrition/products/nutricost-tudca-250mg-capsules?variant=28742426296394

29. TUDCA Plus
http://bit.ly/2Z7V6DJ

30. Back to the Basics: Why Does Liver Health Matter?
http://bit.ly/2XYsL3J

31. Summary of Tauroursodeoxycholic Acid
https://examine.com/supplements/tauroursodeoxycholic-acid/